GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs2243480 | 1 | rs1499614 | chr7:65730798 | CCT6P1 | chr7:65216092-65228661:+ | 0.64 | 5.29 | 7.77E-7 | Diabetic kidney disease |
| THYM | cis | rs1875620 | 1 | rs1502696 | chr9:91545220 | C9orf47 | chr9:91605778-91611055:+ | -0.26 | -4.7 | 8.7E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs1875620 | 1 | rs1502697 | chr9:91545316 | C9orf47 | chr9:91605778-91611055:+ | -0.26 | -4.7 | 8.7E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs10935120 | 1 | rs1534025 | chr3:134313304 | ANAPC13 | chr3:134196547-134204865:- | -0.59 | -8.1 | 1.9E-12 | Height |
| THYM | cis | rs10935120 | 1 | rs1534025 | chr3:134313304 | CEP63 | chr3:134204575-134293852:+ | -0.41 | -5.93 | 4.96E-8 | Height |
| THYM | cis | rs10935120 | 1 | rs1534026 | chr3:134284767 | ANAPC13 | chr3:134196547-134204865:- | 0.58 | 8.01 | 2.88E-12 | Height |
| THYM | cis | rs10935120 | 1 | rs1534026 | chr3:134284767 | CEP63 | chr3:134204575-134293852:+ | 0.41 | 6.04 | 2.93E-8 | Height |
| THYM | cis | rs9309473 | 1 | rs1534471 | chr2:73647508 | ALMS1P | chr2:73872046-73912692:+ | 0.58 | 4.7 | 8.77E-6 | Metabolite levels |
| THYM | cis | rs1535500 | 1 | rs1535500 | chr6:39284050 | KCNK17 | chr6:39266778-39282237:- | -0.47 | -4.8 | 6.01E-6 | Type 2 diabetes |
| THYM | cis | rs2243480 | 1 | rs1546059 | chr7:65654709 | CCT6P1 | chr7:65216092-65228661:+ | -0.67 | -5.68 | 1.48E-7 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs1553174 | chr7:65731194 | CCT6P1 | chr7:65216092-65228661:+ | -0.64 | -5.29 | 7.77E-7 | Diabetic kidney disease |
| THYM | cis | rs17761864 | 1 | rs1555569 | chr17:2149425 | SRR | chr17:2207248-2228553:+ | -0.55 | -5.8 | 8.62E-8 | Esophageal cancer (squamous cell) |
| THYM | cis | rs10461617 | 1 | rs1559282 | chr5:56099375 | C5orf35 | chr5:56205103-56213010:+ | 0.74 | 9.25 | 6.53E-15 | Type 2 diabetes |
| THYM | cis | rs7223966 | 1 | rs15637 | chr17:61772050 | TCAM1P | chr17:61934376-61941738:+ | -0.54 | -4.47 | 2.2E-5 | Body mass index |
| THYM | cis | rs9876781 | 1 | rs1563736 | chr3:48436794 | TREX1 | chr3:48501186-48509043:+ | -0.28 | -4.38 | 3.02E-5 | Longevity |